5-氮杂-2'-脱氧胞苷
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分子式 C8H12N4O4 分子量228.21 Beilstein号 617982 EC号 219-089-4 MDL号 MFCD00043011 PubChem编号 24890797 属性 敏感性 对光线敏感;对热敏感 存贮条件 储存温度
| 货号 | CAS号 | 操作 |
|---|---|---|
| A119533-100mg | 2353-33-5 | 询底价 |
| A119533-1g | 2353-33-5 | 询底价 |
| A119533-25mg | 2353-33-5 | 询底价 |
| A119533-500mg | 2353-33-5 | 询底价 |
| A119533-5mg | 2353-33-5 | 询底价 |
耗材描述
- 分子式 C8H12N4O4
- 分子量228.21
- Beilstein号 617982
- EC号 219-089-4
- MDL号 MFCD00043011
- PubChem编号 24890797
属性
| 敏感性 | 对光线敏感;对热敏感 |
| 存贮条件 | 储存温度2-8℃ |
描述
| 应用 | 5-Aza-2′-deoxycytidine has been used as a demethylating agent in breast cancer cell line, chromatin, DNA and promoter region of p16 gene |
| 产品介绍 | Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation. |
| 生化机理 | 5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression. |
| 别名 | 5-氮杂-2'-脱氧胞苷；5氮杂2脱氧胞嘧啶核苷；地西他滨；5-氮杂-1（2-脱氧-β-D-呋喃核糖基）胞嘧啶;2′-Deoxy-5-azacytidine 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one Decitabine |
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