应用 |
在哺乳动物细胞培养基中可以作谷氨酸盐的替代物,加热灭菌过程中稳定。
L-Glutamine is an essential supplement for cell culture. The free amino acid L-glutamine is unstable and degrades to pyroglutamate. Alanyl-L-glutamine (Ala-Gln) and Gylcyl-L-glutamine (Gly-Gln) are used in cell culture as alternative delivery forms of stabilized L-glutamine. The primary advantage of using L-alanylglutamine in place of L-glutamine is that it reduces the level of ammonia generated during cell culture |
产品介绍 |
无臭;有引湿性。本品在水中易溶,在甲醇中几乎不溶或不溶;在冰醋酸中略溶。 |
生化机理 |
Alanyl-glutamine is a widely used alternative supplement to L-glutamine in the production of biopharmaceuticals. Alanyl-glutamine also acts as an antioxidant (peroxide) and anti-apoptosis (LPS-induced) factor. Ala-Gln has been used in studies on injury and sepsis, and on the effects of irradiation on leucine and protein metabolism in vivo. Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro. |
别名 |
L-丙氨酰-L-谷氨酸盐;丙氨酰-L-谷氨酰胺;力肽; 丙氨酰谷氨酰胺;丙谷二肽;H-Ala-Gln-OH; L-Alanyl-L-glutamine; Glutamine-S;H-Ala-Gln-OH;Alanyl-glutamine |