藤黄酸
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分子式 C38H44O8 分子量628.75 Beilstein号 EC号 MDL号 PubChem编号 属性 沸点 280°C 熔点 81.8°C 溶解性 DMSO: ≥100 mg/mL;H2O: insoluble;Ethanol:1
货号 | CAS号 | 操作 |
---|---|---|
G101480-100mg | 2752-65-0 | 询底价 |
G101480-25mg | 2752-65-0 | 询底价 |
G101480-5mg | 2752-65-0 | 询底价 |
耗材描述
属性
沸点 | 280°C |
熔点 | 81.8°C |
溶解性 | DMSO: ≥100 mg/mL;H2O: insoluble;Ethanol:100 mg/mL |
存贮条件 | 储存温度-20°C |
密度 | 1.2900 |
描述
应用 | 藤黄酸作为蛋白酶激活和凋亡诱导剂,会捕获细胞周期的G2 / M期,而且造成不可逆。 |
产品介绍 | 不溶于水 |
生化机理 | Gambogic acid is a xanthonoid that is derived from the brownish or orange resin from Garcinia hanburyi. This natural chemical has shown promising antitumor activity in clinical trials with mice. Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-xl, Bcl-2, Bcl-w, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM, respectively. Gambogic acid acts as a caspase activator and apoptosis inducer, which causes an irreversible arrest in the G2/M phase of the cell cycle. |
别名 | β-藤黄酸, 1,5-甲醇-1H,3H,11H-呋喃(3,4-g)吡喃(3,2-b)氧杂蒽-1-巴豆酸 ;B"-Guttiferrin Beta-Guttiferrin Beta-Guttilactone Cambogic acid Guttatic acid Guttic acid 1,51,5-Methano-1H,3H,11H-furo(3,4-G)pyrano(3,2-B)xanthene-1-crotonic acid |
标识符号 | GHS06 |
信号词 | Danger |
危害声明 | H301,H315,H319,H335 |
警示性声明 | P261,P301+P310,P305+P351+P338 |
个人防护设备 | Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges |
RTECS | PB9268200 |
WGK德国 | 1 |
风险声明 (欧洲) | R1;R11;R36;R20/21/22; |
安全声明(欧洲) | S26;S36/37; |
危害码(欧洲) | T |
UN代码 | 1356 |
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