蟛蜞菊内酯
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分子式 C16H10O7 分子量314.25 MDL号 MFCD07778564 PubChem编号 24724667 属性 溶解性 Soluble in DMSO (25 mg/mL), and MeOH. 存贮条件 储存温度 2-8°C
| 货号 | CAS号 | 操作 |
|---|---|---|
| W124219-25mg | 524-12-9 | 询底价 |
| W124219-5mg | 524-12-9 | 询底价 |
| W124219-1mg | 524-12-9 | 询底价 |
耗材描述
- 分子式 C16H10O7
- 分子量314.25
- MDL号 MFCD07778564
- PubChem编号 24724667
属性
| 溶解性 | Soluble in DMSO (25 mg/mL), and MeOH. |
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 | Inhibits caspase-11; a key regulator of proinflammatory cytokine IL-1β maturation and apoptosis. |
| 产品介绍 | Wedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis. Mechanistic studies suggest that caspase-11 is inhibited by reduction of NF-κB-mediated transcription. Furthermore, this compound has been shown to inhibit IKKγ, a kinase that is crucial for activation of NF-κB, as well as IKK α and IKK β. Weldelolactone also displays potent trypsin inhibition capacities. Additional studies suggest that Wedelolactone contains antagonistic properties towards two PLA2 myotoxins that were isolated from Agkistrodon contortix laticinctus and Crotalus virdis virdis. This agent has also been noted to contain antihepatotoxic behavior consequentially protecting primary cultured liver cells from the toxicity of CC14, Phalloidin, and galactosamine, and inhibit 5-lipoxygenase (5-LO)) activity in porcine leukocytes. |
| 生化机理 | Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt. |
| 别名 | 7-甲氧基-5,11,12- 三羟基香豆素;1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one; 7-Methoxy-5,11,12-trihydroxycoumestan;IKK Inhibitor II; Eclipta alba |
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