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GSK2983559 active metabolite

CAS No. : 1423186-80-4

MCE 国际站：GSK2983559 active metabolite

产品活性：GSK2983559 active metabolite 是 GSK2983559 的活性代谢物。GSK2983559 active metabolite 是一种受体相互作用蛋白-2 (RIP2) 激酶抑制剂，详细信息请参考专利 WO/2014043446 A1 中的化合物 example 1。

研究领域：Apoptosis

作用靶点：RIP kinase

In Vitro: GSK2983559 active metabolite is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase, which is also referred to as CARD3, RICK, CARDIAK, or RIPK2, is a TKL family serine/threonine protein kinase involved in innate immune signaling. RIP2 kinase is composed of an N-terminal kinase domain and a C-terminal caspase-recruitment domain (CARD) linked via an intermediate (IM) region. The CARD domain of RIP2 kinase mediates interaction with other CARD-containing proteins, such as NODI and NOD2. NODI and NOD2 are cytoplasmic receptors which play a key role in innate immune surveillance. They recognize both gram positive and gram negative bacterial pathogens and are activated by specific peptidoglycan motifs, diaminopimelic acid (i.e., DAP) and muramyl dipeptide.

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