MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 148081-72-5
MCE 国际站:HTHQ
产品活性:HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone) 是一种强力的亲脂性酚类抗氧化剂。HTHQ 通过与活性氧 (ROS) 直接反应并清除 ROS 以形成更稳定的自由基而具有很强的抗氧化活性。
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
作用靶点:Reactive Oxygen Species
In Vitro: HTHQ (0-100 μM; 24 hours; PC12 cells) treatment increases cell viabilities in a dose-dependent manner.
HTHQ (10 μM; 0.6-24 hours; PC12 cells) inhibits 3,4-L-Dihydroxyphenylalanine (L-DOPA) -induced phosphorylation of sustaines extracellular signal-regulated kinases (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK1/2). HTHQ also normalizes L-DOPA-reduced Bcl-2-associated death protein (Bad) phosphorylation and Bcl-2-associated X protein (Bax) expression, promoting cell survival.
In Vivo: HTHQ (50-200 mg/kg; oral administration; for 4 weeks; specific pathogen-free male Sprague Dawley rats) treatment significantly improves liver weight and serum chemistry level. HTHQ reduces hydroxyproline and malondialdehyde level in the liver. HTHQ treatment also reduces fibrotic septa. HTHQ administration shows reduced mRNA level of PDGF (Plateletderived growth factor) , α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β) than DMN-induced hepetic fibrosis animals in the liver tissue.
相关产品:Clinical Compound Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Oxygen Sensing Compound Library | Ferroptosis Compound Library | Pyroptosis Compound Library | Mitochondria-Targeted Compound Library | Targeted Diversity Library | Protein-protein Interaction Inhibitor Library | Human Metabolite Library | D-α-Hydroxyglutaric acid disodium | 8α-Tigloyloxyhirsutinolide 13-O-acetate | Anticancer agent 120 | 7-Hydroxy-4-methyl-2(1H)-quinolone | N-tert-Butyl-α-phenylnitrone-d14 | BDP 581/591 NHS ester | Cysteamine-d4 hydrochloride | L-Ascorbic acid sodium salt | Manganese(salen) chloride | Hydroxyphenyl Fluorescein | Glucosamine sulfate | Maresin 1 | Berberine | 1,3-Dicaffeoylquinic acid | Ciprofloxacin | Echinocystic acid | Lacto-N-fucopentaose I | Nisoldipine-d6 | Arg-Tyr | HKPerox-2 | 3-Indolepropionic acid | 2-Methoxyestradiol-13C,d3 | Albendazole | QD394 | AKBA | Cedrin | Deferoxamine | Ellagic acid | Acetylcysteine-d3 | N-Acetyl-D-cysteine
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。