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CAS No. : 302803-72-1
MCE 国际站:Ciliobrevin A
产品活性:Ciliobrevin A (HPI-4) 是一种 Hedgehog (Hh) 信号通路抑制剂,平均抑制浓度 (IC50) 值小于 10 μM。
研究领域:Stem Cell/Wnt
作用靶点:Hedgehog
In Vitro: Ciliobrevin A (HPI-4) also prevents an increase in the FLAG-Gli2 full-length/repressor ratio upon Shh stimulation, but HPI-2 and HPI-3 have no significant effect. Ciliobrevin A decreases FLAG-Gli1 stability in these cells, revealing another mechanism by which this small molecule can inhibit Hh target gene expression, while neither HPI-2 or HPI-3 has any significant effect on FLAG-Gli1 levels. Ciliobrevin A increases ciliary levels of FLAG-Gli2 in a manner disproportionate to their effects on total FLAG-Gli2 levels. In addition, Shh-EGFPFLAG-Gli2 cells cultured with Ciliobrevin A have truncated primary cilia, and this cellular organelle is absent in a significant fraction of Ciliobrevin A-treated cells. Ciliobrevin A also perturbs primary cilia formation in the Shh-LIGHT2FLAG-Gli1 cells and promotes accumulation of FLAG-Gli1 at the distal tip of this organelle. Ciliobrevin A significantly inhibits the proliferation of these neuronal progenitors, as measured by histone H3 phosphorylation (pH3) levels, and reduces cellular levels of cyclin D1 protein and Gli1, Gli2, and N-Myc transcripts in the CGNPs. Ciliobrevin A can block the proliferation of SmoM2-expressing CGNPs and should be equally potent against CGNPs lacking Su(fu) function, whereas the Smo inhibitor Cyclopamine is ineffective against either oncogenic lesion.
相关产品:Bioactive Compound Library Plus | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Differentiation Inducing Compound Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Targeted Diversity Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Cancer Stem Cells Compound Library | Membrane Protein-targeted Compound Library | RU-SKI 43 | Hh-Ag1.5 | Vismodegib | Ciliobrevin D | RL-0070933 | Hedgehog IN-2 | Itraconazole-d3 | Neurodazine | Itraconazole | Hedgehog IN-3 | Dynarrestin | Cyclopamine | SMO-IN-3 | TPB15 | SANT-1 | HSP70-IN-3 | Robotnikinin | SMO-IN-2 | Itraconazole-d9 | JK184 | 3-epi-Vitamin D3 | Hedgehog IN-5 | SANT 2 | MK-4101 | CUR61414 | Jervine | SMANT hydrochloride | TAK-441
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