MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

BBT594

CAS No. : 882405-89-2

MCE 国际站：BBT594

产品活性：BBT594 是一种有效的受体酪氨酸激酶 RET 抑制剂，常用于癌症研究。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：RET

In Vitro: NVP-BBT594 blocks the GDNF-mediated enhancement of MCF7-LTED cell viability in 2D culture and 3D colony formation. The addition of 10 pM E2, to mimic the E2 level in post-menopausal patients that have relapsed on AI treatment and ceased AI therapy, increases 3D colony formation of both MCF7 and MCF7-LTED cells, and this effect is efficiently reverted by NVP-BBT594. Parental T47D cells cultured in presence of low level E2, GFRα1/GDNF stimulation results in increased 3D colony formation, which is significantly reverted by NVP-BBT594. NVP-BBT594 targets GDNF-RET signaling and sensitizes MCF7-2A cells to letrozole treatment. NVP-BBT594 impairs GDNF-mediated RET downstream signaling and significantly enhances the antiproliferative effects of letrozole. NVP-BBT594 shows the highest suppression of GDNF-induced RET signaling, as assessed by RET, ERK1/2, AKT and ER phosphorylation. NVP-AST487 and NVP-BBT594 have comparable RET inhibitory activity in wild-type MCF7 cells.

相关产品：Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Anti-Cancer Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Liver Cancer Compound Library   |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  trans-Pralsetinib  |  RET-IN-24  |  BT-13  |  RET-IN-16  |  WF-47-JS03  |  Pyrazoloadenine  |  GSK3179106  |  RET-IN-1  |  Lenvatinib-d₅  |  Pz-1  |  Regorafenib monohydrate  |  RET-IN-14  |  AD57  |  AD80  |  FLT3/ITD-IN-4  |  RET-IN-18  |  Regorafenib-¹³C,d₃  |  RET V804M-IN-1  |  RET-IN-19  |  Enbezotinib  |  RET-IN-6  |  BT44  |  TG101209  |  Regorafenib-d₃  |  Amuvatinib  |  WHI-P180  |  RET-IN-10

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。