MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Osalmid

CAS No. : 526-18-1

MCE 国际站：Osalmid

产品活性：Osalmid是核糖核苷酸还原酶小亚基M2（RRM2）的靶向化合物；抑制核糖核苷酸还原酶活性的IC₅₀值为8.23 μM。

研究领域：Anti-infection

作用靶点：HBV

In Vitro: Osalmid is identified as a potential ribonucleotide reductase small subunit M2 (RRM2) compound. Osalmid is 10-fold more active in inhibiting ribonucleotide reductase (RR) activity than hydroxyurea, and significantly inhibits HBV DNA and cccDNA synthesis in HepG2.2.15 cells in a time- and dose-dependent manner. After treatment for 8 days with Osalmid, the EC₅₀ for HBV DNA inhibition are 11.1 μM for culture supernatant and 16.5 μM for cells. Osalmid suppresses RR activity in a concentration-dependent manner, with an IC₅₀ of 8.23 μM. Osalmid is shown to possess potent activity against a 3TC-resistant HBV strain, suggesting utility in treating drug-resistant HBV infections.

In Vivo: Osalmid reduces RR activity and HBV replication in HBV-transgenic mice and shows a synergistic efficacy with 3TC without significant toxicity. Oral dosing of osalmid at 400 mg/kg/d results in a time-dependent inhibition of HBV DNA replication. After treatment for 4 weeks, osalmid suppresses HBV DNA replication by about 40-45% as compared to the control in mouse sera and liver tissues.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  FDA-Approved Drug Library  |  Antiviral Compound Library  |  Drug Repurposing Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  FDA Approved & Pharmacopeial Drug Library  |  Off-patent Drug Library  |  Mitochondrial Toxicity Compound Library  |  FNC-TP  |  Tuvirumab  |  Bicyclol  |  Catalpol  |  (5S,8R)-HBV-IN-10  |  Glycosmisic acid  |  RO8191  |  Adefovir-d₄  |  Swertianolin  |  Tiviciclovir  |  (1R)-Tenofovir amibufenamide  |  2'-Deoxy-L-adenosine  |  HBV-IN-13  |  AB-423  |  Brain Derived Basic Fibroblast Growth Factor (1-24)  |  Pseudolaric Acid B  |  Canocapavir  |  RG7834  |  Periglaucine B  |  HBV-IN-10  |  Adefovir dipivoxil  |  Lagociclovir valactate  |  LPRP-Et-97543  |  HBV-IN-4  |  HBV-IN-17  |  AB-836  |  Telbivudine-d₄  |  Tenofovir Disoproxil fumarate  |  Vebicorvir  |  HBV-IN-16

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。