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Emrusolmin

CAS No. : 882697-00-9

MCE 国际站：Emrusolmin

产品活性：Emrusolmin (Anle138b) 是一种低聚物聚集抑 (oligomeric aggregation ) 调节剂，可阻断朊病毒蛋白 (PrPSc) 和 α-突触核蛋白 (α-syn) 病理性聚集的形成。Emrusolmin 在体内强烈抑制低聚物积累、神经元变性和疾病进展。Emrusolmin 毒性低，口服生物利用度高，血脑屏障通透性好。Emrusolmin 阻断 Aβ 通道并挽救淀粉样变性小鼠模型的疾病表型。

研究领域：Neuronal Signaling

作用靶点：Amyloid-β

In Vitro: Oligomeric aggregates are presumed to be the key neurotoxic agent. Emrusolmin blocksthe formation of pathological aggregates of prion protein and of α-synuclein, which is deposited in Parkinson’s disease and other synucleinopathies such as dementia with Lewy bodies and multiple system atrophy. Emrusolmin strongly inhibits all prion strains tested including BSE-derived and human prions. Emrusolmin shows structure-dependent binding to pathological aggregates and strongly inhibits formation of pathological oligomers both for prion protein and α-synuclein.

In Vivo: Emrusolmin shows structure-dependent binding to pathological aggregates and strongly inhibits formation of pathological oligomers in vitro and in vivo both for prion protein and α-synuclein.
Emrusolmin (0.6-2 g/kg; p.o.) modulates α‐synuclein oligomerization.

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