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T807

CAS No. : 1415379-56-4

MCE 国际站：T807

产品活性：T807是一种新型的tau正电子发射断层扫描 (PET) 示踪剂。

研究领域：Neuronal Signaling

作用靶点：Tau Protein

In Vitro: Aggregated tau protein is a major neuropathological substrate central to the pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD). In vitro autoradiography results show that [¹⁸F]T807 exhibits strong binding to PHF-tau positive human brain sections (K_d=14.6 nM). A comparison of autoradiography and double immunohistochemical staining of PHF-tau and Ab on adjacent sections demonstrates that [¹⁸F]T807 binding colocalizes with immunoreactive PHF-tau pathology, but does not highlight Ab plaques. [¹⁸F]T807 strongly binds to tau lesions primarily made of paired helical filaments in Alzheimer’s brains e.g. intra and extraneuronal tangles and dystrophic neurites. [¹⁸F]T807 off-target binding to neuromelanin- and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions is identified.

In Vivo: [¹⁸F]T807 is able to cross the blood–brain barrier and ished out quickly in mice model. [¹⁸F]T807 clears rapidly from the brain, with activity values decreasing from 4.43% ID/g at 5 minutes to 0.62% ID/g at 30 minutes. Kidney elimination is a significant clearance pathway, resulting in a maximum tracer concentration of 14.99% ID/g in the kidneys at 5 minutes, which decreases to 5.52% ID/g at 30 minutes. The accumulation of activity in muscle and bone remain relatively low throughout the PET scan.

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