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DHBP dibromide

CAS No. : 6159-05-3

MCE 国际站：DHBP dibromide

产品活性：DHBP dibromide是钙离子释放的抑制剂和肌肉松弛剂。

研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：Calcium Channel

In Vitro: DHBP inhibits the calcium release induced by 2 mM caffeine and 2 μg/mL polylysine with an IC₅₀ value of 5 μg/mL and 4 μg/mL, respectively. DHBP inhibits [³H]-ryanodine binding in a dose-dependent manner with an IC₅₀ of 2.5 μg/mL and 90-100% inhibition at 20-30 μg/mL. Calcium uptake by SR is inhibited in the presence of caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 fLM ryanodine are blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor.

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