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inS3-54A18

CAS No. : 328998-53-4

MCE 国际站：inS3-54A18

产品活性：inS3-54A18 是有一种有效的 STAT3 抑制剂，具有抗癌作用。

研究领域：JAK/STAT Signaling  |  Stem Cell/Wnt

作用靶点：STAT

In Vitro: inS3-54A18 (5 μM) reduces wound healing to 64% and 76% for A549 and MDA-MB-231 cells, respectively. inS3-54A18 at 10 μM further reduces the healing to 47% and 39%, respectively. inS3-54A18 inhibits the expression of STAT3 downstream target genes and the binding of STAT3 to its endogenous target sequences. inS3-54A18 does not affect the constitutive or IL-6-induced STAT3 activation (Tyr705 phosphorylation) but represses STAT3 target gene (survivin) expression.

In Vivo: inS3-54A18 (200 mg/kg, p.o.) inhibits tumor growth, metastasis and expression of STAT3 target genes in a mouse xenograft model of A549 cells.

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