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CAS No. : 849550-05-6
MCE 国际站:Cevipabulin
产品活性:Cevipabulin (TTI-237) 是一种微管活性的、口服有效的抗肿瘤化合物,可抑制 [3H] 长春碱与微管蛋白的结合,对人癌细胞的 IC50 值为 18-40 nM。
研究领域:Cell Cycle/DNA Damage | Cytoskeleton
作用靶点:Microtubule/Tubulin
In Vitro: Cevipabulin (0-50 nM, 72 hours) shows good activity (between 18 and 40 nM IC50 values) on cell lines from ovarian, breast, prostate, and cervical tumors.
Flow cytometry experiments reveal that, Cevipabulin (TTI-237) at low concentrations (20-40 nM) produces sub-G1 nuclei and, at concentrations above 50 nM, it causes a strong G2-M block.
In Vivo: Cevipabulin (TTI-2370)( 5, 10, 15, and 20 mg/kg, every 4 days for 4 cycles, in mice) is active by i.v. and p.o. administration against human tumor xenografts, showing dose-dependent effects, with good antitumor activity at 20 and 15 mg/kg.
相关产品:Clinical Compound Library Plus | Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Anti-Aging Compound Library | Cytoskeleton Compound Library | Anti-Lung Cancer Compound Library | Protein-protein Interaction Inhibitor Library | Heterocyclic Compound Library | Tirbanibulin dihydrochloride | Tubulysin IM-3 | AMXI-5001 hydrochloride | Tubulin polymerization-IN-21 | Dolastatin 10 | SB-216 | MAP4343 | Tubulin polymerization-IN-8 | Tubulysin IM-1 | Colchicine-d3 | 2-Methoxyestradiol-13C,d3 | Taltobulin | Albendazole | Tilavonemab | DM4-d6 | EGFR-IN-57 | Epothilone B | Epothilone A | Maytansinol | Docetaxel-d9 | Verubulin hydrochloride | VcMMAE | Tubulin polymerization-IN-15 | Combretastatin A-1 | Tubulin/HDAC-IN-1 | Mc-MMAE | 7-epi-Taxol | Thiocolchicine | Fosbretabulin disodium | PEG4-aminooxy-MMAF
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
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