MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Adelmidrol

CAS No. : 1675-66-7

MCE 国际站：Adelmidrol

产品活性：Adelmidrol 发挥重要的抗炎作用，部分依赖于 PPARγ。Adelmidrol 降低 NF-κB 易位，和 COX-2 表达。

研究领域：NF-κB  |  Immunology/Inflammation  |  Cell Cycle/DNA Damage  |  Vitamin D Related/Nuclear Receptor

作用靶点：NF-κB  |  COX  |  PPAR

In Vitro: Adelmidrol is a palmitoylethanolamide analogue. Adelmidrol reduces NF-κB translocation, COX-2, and p-ERK expression; proinflammatory cytokine release; and the incidence of nitrotyrosine and poly(ADP)ribose in the colon.

In Vivo: Adelmidrol (10 mg/kg, o.s.) reduces significantly the degree and severity of the macroscopic and histologic signs of colon injury. Moreover, 4 days after colitis induced by dinitrobenzene sulfonic acid (DNBS) treatment, all mice have diarrhea and a reduction in body weight (compared with the sham groups). Adelmidrol (10 mg/kg, o.s.) treatment significantly reduces the loss of body weight. The inflammatory bowel disease (IBD) induced by DNBS intrarectally administered is also characterized by an augmentation in myeloperoxidase (MPO) activity, an indicator of neutrophil accumulating in the colon. This is consistent with light microscopic observations showing the colon of vehicle-treated DNBS mice to contain a large number of neutrophils. In contrast, Adelmidrol (10 mg/kg, o.s.) significantly reduces the degree of polymorphonuclear cell infiltration (determined as reduction in MPO activity) in inflamed colon.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Immunology/Inflammation Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Clinical Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Antioxidant Compound Library  |  Differentiation Inducing Compound Library  |  Oxygen Sensing Compound Library  |  Pyroptosis Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Anti-Obesity Compound Library  |  Transcription Factor-Targeted Library  |  Lipid Metabolism Compound Library   |  Anti-Liver Cancer Compound Library   |  Anti-Colorectal Cancer Compound Library   |  Antidepressant Compound Library  |  Human Metabolite Library  |  Anti-Prostate Cancer Compound Library  |  Nuclear Receptor Compound Library  |  Osteogenesis Compound Library  |  Cancer Stem Cells Compound Library  |  Pain-Related Compound Library  |  Mitochondrial Protection Compound Library  |  Highly Selective Inhibitors Library  |  Highly Selective Activators Library  |  Meloxicam-d₃-1  |  4-Methylamino antipyrine hydrochloride  |  Vedaprofen-d₃  |  Pelubiprofen-¹³C,d₃  |  IMD-ferulic  |  Karacoline  |  5-Hydroxy tryptophol β-D-glucuronide-d₄  |  N-tert-Butyl-α-phenylnitrone-d₁₄  |  Mangiferin  |  Dauricine  |  Tepoxalin  |  (rac)-AG-205  |  Ampyrone  |  LY518674  |  Pectolinarigenin  |  Ermanin  |  Poricoic acid A  |  Aceclofenac-d₄  |  Bocidelpar  |  Ginsenoside Rg1  |  Retinoic acid  |  GS143  |  SC-58125  |  QNZ  |  5-Aminosalicylic Acid-d₃ hydrochloride  |  Lucyoside B  |  Salicylic acid-¹³C₆  |  (±)-Naproxen-d₃-1  |  Sulindac  |  Colistin adjuvant-1

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。