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CAS No. : 26016-98-8
MCE 国际站:Fosfomycin calcium
产品活性:Fosfomycin (MK-0955) calcium 是一种能透过血脑屏障的广谱抗生素,不可逆地抑制细胞壁合成的早期阶段。Fosfomycin calcium 对多种细菌具有杀菌活性,这些细菌包括耐多药 (MDR),广泛耐药 (XDR) 和耐全药 (PDR) 细菌。
研究领域:Anti-infection
作用靶点:Bacterial | Antibiotic
In Vitro: Fosfomycin calcium is an epoxy antibacterial agent. Compared with other antibacterial agents, it acts by inhibiting the early process of cell wall synthesis.
Fosfomycin calcium has bactericidal activity against a variety of gram-negative and gram-positive pathogens, including broad-spectrum production β-Bacteria of lactamase and carbapenemase, and against S. aureus strains with an inhibition rate of 90%.
Fosfomycin calcium displays extensive tissue penetration, can be used to research of infections of the CNS, soft tissues, bone, lungs, and abscesses.
In Vivo: Fosfomycin calcium (80 mg/kg; i.v.-i.v. or i.v.-p.o.) displays the protective effect on the nephrotoxicity of double beckacin, and is not affected by different administration routes.
Pharmacokinetic of Fosfomycin calcium in Rats
Dibekacin Dose (mg) | Vdss (l/kg) | β (min-1) | T1/2 (min) | Urinary recovery (%) |
30 | 0.261 | 0.0244 | 28.4 | 85 |
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