MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Secnidazole

CAS No. : 3366-95-8

MCE 国际站：Secnidazole

产品活性：Secnidazole (RP-14539) 是一种唑类抗生素和黏质沙雷菌毒力的咪唑缓释剂，具有口服活性。Secnidazole 作为一种类似于酰基高丝氨酸内酯，能有效抑制 QS 导致铜绿假单胞菌的发病衰减。Secnidazole 在体外对多种厌氧革兰氏阴性和革兰氏阳性细菌均有抗菌活性。Secnidazole 可用于各种疾病的研究，如阿米巴病和贾第虫病，以及细菌性阴道炎。

研究领域：Anti-infection

作用靶点：Parasite  |  Antibiotic  |  Bacterial

In Vitro: Secnidazole (RP-14539) (0-5000 μM; 5 or 10 min) inhibits CYP2C19 and CYP3A4, with IC₅₀ values of 3873 μM and 3722 μM, respectively.
Secnidazole (0-5000 μM; 5 or 10 min) does not exhibit time-dependent inhibition.
Secnidazole (0-5000 μM; 5 or 10 min) has an apparent IC₅₀ value of 503 μM for direct inhibition of human ALDH2.
Secnidazole (0-5000 μM; 5 or 10 min) has concentration-dependent inhibition at higher concentration with some of the CYP isoforms notably CYP2A6, CYP2B6, and CYP2D6.
Secnidazole (10 μL; 20 h; the secnidazole solution was two-fold serially diluted using Mueller–Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL) inhibits S.marcescens growth with a MIC₅₀ value of 10 mg/mL.

In Vivo: Secnidazole (100 μL; ip.; for 5 days) has protective activity against S.marcescens pathogenesis and can diminish its pathogenesis in mice.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  FDA-Approved Drug Library  |  Drug Repurposing Compound Library  |  Antibacterial Compound Library  |  NMPA-Approved Drug Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Antibiotics Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Antiparasitic Compound library  |  Children’s Drug Library  |  Human Metabolite Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Off-patent Drug Library  |  Antifungal agent 26  |  Myricetin 3-O-α-L-arabinopyranoside  |  (1R,2S,7R)-Sitafloxacin-d₄ hydrochloride  |  Quinidine-d₃  |  Nebacumab  |  Angulatin G  |  Acridine Orange base  |  N-Desethyl amodiaquine-d₅  |  Doxorubicin-¹³C,d₃ TFA  |  Gepotidacin  |  Amycolatopsin A  |  Palitantin  |  Antibiotic A-33853  |  Estradiol hemihydrate  |  Sulbactam-d₂ sodium  |  Antimicrobial agent-5  |  Proguanil-d₆  |  NBTIs-IN-4  |  Proanthocyanidins  |  Anticancer agent 120  |  Azlocillin sodium salt  |  Antitubercular agent-13  |  Toyocamycin  |  Methyl palmitate  |  Lenampicillin hydrochloride  |  Hispolon  |  PC58538  |  SPR206 acetate  |  Caracemide

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。