MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Flufenamic acid

CAS No. : 530-78-9

MCE 国际站：Flufenamic acid

产品活性：Flufenamic acid 是一种非甾体类抗炎剂，能够抑制 COX 的活性，激活 AMPK 的活性，调节离子通道，阻滞氯离子通道 (chloride channel) 和 L-型钙离子通道 (L-type Ca²⁺ channel)，调节非选择性阳离子通道，激活钾离子通道 (K⁺ channel) 等。Flufenamic acid 与TEAD2 YBD 的中央囊袋结合，抑制 TEAD 功能和 TEAD-YAP 依赖性过程，如细胞迁移和增殖。

研究领域：Immunology/Inflammation  |  PI3K/Akt/mTOR  |  Epigenetics  |  Membrane Transporter/Ion Channel  |  Neuronal Signaling  |  Anti-infection

作用靶点：COX  |  AMPK  |  Potassium Channel  |  Chloride Channel  |  Calcium Channel  |  Parasite

In Vitro: Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), and also modulates ion channels, blocking chloride channels and L-type Ca²⁺ channels, modulating non-selective cation channels (NSC), activating K⁺ channels. Flufenamic acid inhibits a wide spectrum of TRP channels, including: C3, C7, M2, M3, M4, M5, M7, M8, V1, V3, and V4 but activates at least two TRP channels (C6 and A1). Flufenamic acid induces AMPK activation in T84 cells, and such an effect is via a direct stimulation of calcium/calmodulin-dependent protein kinase kinase beta (CaMKKβ) activity. Moreover, Flufenamic acid (FFA; 5-50 μM) dose-dependently inhibits cAMP-dependent Cl^- secretion in intact T84 cells, suppresses CFTR-mediated apical I_Cl^-, and blocks the Ca²⁺-dependent Cl^- secretion in a dose-dependent manner with IC₅₀ of appr 10 μM and near complete inhibition at 100 μM in T84 cell monolayers, but shows no effect on Na⁺-K⁺ ATPase or NKCC in T84 cells.

In Vivo: Flufenamic acid (50 mg/kg, i.p.) has anti-inflammatory effect in a mouse model of Vibrio cholerae El Tor variant (EL)-induced diarrhea and significantly abrogates EL-induced intestinal fluid secretion and barrier disruption at 20 mg/kg. Furthermore, Flufenamic acid suppresses NF-κB nuclear translocation and expression of proinflammatory mediators and promotes AMPK phosphorylation in the EL-infected mouse intestine.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  Membrane Transporter/Ion Channel Compound Library  |  Neuronal Signaling Compound Library  |  PI3K/Akt/mTOR Compound Library  |  FDA-Approved Drug Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Antioxidant Compound Library  |  Oxygen Sensing Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  Glycolysis Compound Library  |  Cytoskeleton Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Neuroprotective Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Antiparasitic Compound library  |  Anti-Cancer Metabolism Compound Library  |  Anti-Obesity Compound Library  |  Lipid Metabolism Compound Library   |  Glucose Metabolism Compound Library  |  Calcium Channel Blocker Library  |  Potassium Channel Compound Library  |  Human Metabolite Library  |  Non-steroidal Anti-Inflammatory Compound Library  |  Pain-Related Compound Library  |  Off-patent Drug Library  |  Antihypertensive Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Mitochondrial Toxicity Compound Library  |  Highly Selective Inhibitors Library  |  Highly Selective Activators Library  |  Antifungal agent 26  |  Mitiglinide-d₅ calcium  |  Quinidine-d₃  |  Angulatin G  |  Acridine Orange base  |  N-Desethyl amodiaquine-d₅  |  Palitantin  |  Benidipine hydrochloride  |  Proguanil-d₆  |  Azlocillin sodium salt  |  Meloxicam-d₃-1  |  4-Methylamino antipyrine hydrochloride  |  Vedaprofen-d₃  |  Methyl palmitate  |  Pelubiprofen-¹³C,d₃  |  Ropivacaine hydrochloride  |  Isotachysterol 3  |  HBPC–GSH  |  Doxycycline calcium  |  N-tert-Butyl-α-phenylnitrone-d₁₄  |  IAA65  |  Ranolazine-d₈ dihydrochloride  |  Diltiazem hydrochloride  |  WX-081  |  SQ109  |  13,21-Dihydroeurycomanone  |  Palmitoylglycine  |  Nevirapine  |  Phenyl benzoate

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。