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CAS No. : 54-36-4
MCE 国际站:Metyrapone
产品活性:Metyrapone (Su-4885) 是一种有效且具有口服活性的 11β-羟化酶 (11β-hydroxylase) 抑制剂,可抑制醛固酮 (aldosterone) 的产生,也是一种细胞自噬 (autophagy) 激活剂。Metyrapone 能抑制内源性肾上腺皮质激素的合成,也会影响行为和情绪。此外,Metyrapone 可通过下调 mTOR 通路增加自噬过程的效率,也能与恶臭假单胞菌 (Pseudomonas putida) 细胞色素 P-450 (CYP450) 相互作用。Metyrapone 可用于研究库兴氏综合征 (Cushing's syndrome) 和抑郁症。
研究领域:Metabolic Enzyme/Protease | Autophagy
作用靶点:Endogenous Metabolite | Cytochrome P450 | Autophagy
In Vitro: Metyrapone (100 μM; 2 h) hyperactivates autophagy in HepG2, and delays the activation of apoptosis at severe endoplasmic reticulum (ER) stress.
In Vivo: Metyrapone (25 or 50 mg/kg; SC, single dosage) decreases the stress-induced increase in plasma corticosterone levels, significantly impairs acquisition performance at high dosage, and increases open arm activity at low dosage.
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