MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Amodiaquine dihydrochloride dihydrate

CAS No. : 6398-98-7

MCE 国际站：Amodiaquine dihydrochloride dihydrate

产品活性：Amodiaquine dihydrochloride dihydrate (Amodiaquin dihydrochloride dihydrate) 是一种4-氨基喹啉类抗疟剂，是一种有效的具有口服活性的组胺 N-甲基转移酶 (histamine N-methyltransferase) 抑制剂。Amodiaquine dihydrochloride dihydrate 也是一种 Nurr1 激动剂，可特异性结合 Nurr1 的配体结合域，EC₅₀ 为 ~20 μM。抗炎作用。

研究领域：Anti-infection  |  Epigenetics

作用靶点：Parasite  |  Histone Methyltransferase

In Vitro: Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH⁺ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells.

In Vivo: Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.

相关产品：Drug Repurposing Compound Library Plus  |  FDA-Approved Drug Library Plus  |  FDA-Approved Drug Library Mini  |  Bioactive Compound Library Plus  |  Anti-Infection Compound Library  |  Epigenetics Compound Library  |  Immunology/Inflammation Compound Library  |  FDA-Approved Drug Library  |  Histone Modification Research Compound Library  |  Antiviral Compound Library  |  Drug Repurposing Compound Library  |  Reprogramming Compound Library  |  Anti-COVID-19 Compound Library  |  NMPA-Approved Drug Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  FDA Approved & Pharmacopeial Drug Library  |  Neuroprotective Compound Library  |  Drug-Induced Liver Injury (DILI) Compound Library  |  Anti-Blood Cancer Compound Library  |  Antiparasitic Compound library  |  Children’s Drug Library  |  Human Metabolite Library  |  Nuclear Receptor Compound Library  |  Heterocyclic Compound Library  |  Off-patent Drug Library  |  Membrane Protein-targeted Compound Library  |  Highly Selective Inhibitors Library  |  Antifungal agent 26  |  Quinidine-d₃  |  Angulatin G  |  Acridine Orange base  |  N-Desethyl amodiaquine-d₅  |  PRMT5-IN-17  |  Palitantin  |  Proguanil-d₆  |  Azlocillin sodium salt  |  Methyl palmitate  |  HBPC–GSH  |  Doxycycline calcium  |  EZM0414  |  BIX-01294  |  SQ109  |  13,21-Dihydroeurycomanone  |  Nevirapine  |  Monensin sodium salt  |  WDR5-IN-5  |  Clindamycin phosphate  |  PRMT5-IN-22  |  1-Deacetylnimbolinin B  |  KDU731  |  Gambogenic acid  |  (E)-Fenpyroximate  |  Niclosamide monohydrate  |  SGC707  |  Antimalarial agent 8  |  Dot1L-IN-7

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。