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(-)-Blebbistatin

CAS No. : 856925-71-8

MCE 国际站：(-)-Blebbistatin

产品活性：(-)-Blebbistatin 是选择性的非肌肉肌球蛋白 II (myosin II) ATPase 活性的抑制剂。

研究领域：Cytoskeleton

作用靶点：Myosin

In Vitro: Blebbistatin potently inhibits several striated muscle myosins as well as vertebrate nonmuscle myosin IIA and IIB with IC₅₀ values ranging from 0.5 to 5 μM. Smooth muscle myosin is only poorly inhibited (IC₅₀=80 μM). Blebbistatin does not compete with nucleotide binding to the skeletal muscle myosin subfragment-1. The inhibitor preferentially binds to the ATPase intermediate with ADP and phosphate bound at the active site, and it slows down phosphate release. It blocks the myosin heads in a products complex with low actin affinity. In culture-activated hepatic stellate cells, blebbistatin is found to change both cell morphology and function. Stellate cells become smaller, acquire a dendritic morphology and have less myosin IIA-containing stress fibres and vinculin-containing focal adhesions. Blebbistatin impairs silicone wrinkle formation, reduces collagen gel contraction and blocks endothelin-1-induced intracellular Ca²⁺ release. It promotes wound-induced cell migration.

In Vivo: Blebbistatin dose-dependently and completely relax both KCl- and carbachol-induced rat detrusor and endothelin-1-induced human bladder contraction. Pre-incubation with 10 μM blebbistatin attenuates carbachol responsiveness by 65% while blocking electrical field stimulation-induced bladder contraction reaching 50% inhibition at 32 Hz.

相关产品：Bioactive Compound Library Plus  |  Peptidomimetic Library  |  Myosin V-IN-1  |  ATM-3507 trihydrochloride  |  Omecamtiv mecarbil-d₈  |  HA-100 hydrochloride  |  Danicamtiv  |  Blebbistatin  |  Mavacamten  |  MT-134  |  JB002  |  16-38-Thymosin β4 (cattle) (TFA)  |  para-Nitroblebbistatin  |  Kemptamide  |  MLCK inhibitor peptide 18  |  W-7 hydrochloride  |  BTS  |  JB062  |  Pentachloropseudilin  |  Sevasemten  |  Aficamten  |  MPH-220  |  ML-7 hydrochloride  |  Para-aminoblebbistatin  |  Omecamtiv mecarbil  |  JB061  |  ML-9 Free Base

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