MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 13492-01-8
MCE 国际站:Tranylcypromine hemisulfate
产品活性:Tranylcypromine (SKF 385) hemisulfate 是一种不可逆的非选择性单胺氧化酶 (MAO) 抑制剂,可用于研究抑郁症。Tranylcypromine hemisulfate 还是一种赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂,可抑制病变的生长并改善患有子宫内膜异位症的小鼠的全身痛觉过敏。
研究领域:Neuronal Signaling | Epigenetics
作用靶点:Monoamine Oxidase | Histone Demethylase
In Vitro: Tranylcypromine (10 nM to 10 μM) exerts neuroprotective effects against toxicity induced by human Aβ(1-42) oligomers independently from the presence of glial cells. Tranylcypromine (100 μM) significantly protects RGCs from glutamate neurotoxicity-induced apoptosis as well as apoptosis induced by oxidative stress. Tranylcypromine promotes mitogen-activated protein kinase 12 (p38 MAPKγ) expression under conditions of glutamate (Glu)-induced stress. Besides, tranylcypromine contributes to RGC survival via alterations of p38 MAPKγ activity.
In Vivo: Tranylcypromine treatment significantly and substantially reduces the lesion size and improves generalized hyperalgesia in a dose-dependent fashion in mice with induced endometriosis. In addition, tranylcypromine treatment results in reduced immunoreactivity to biomarkers of proliferation, angiogenesis, and H3K4 methylation, leading to arrested EMT and lesion growth. Tranylcypromine (500 mM) injection exerts neuroprotective effects within intracellular apoptotic signaling pathways and suppresses morphologic changes in the retina of the rat, suppresses caspase 3 activity and recovers p38 MAPKγ expression in the retina after NMDA-induced injury, and enhances RGC survival after retinal injury via the attenuation of NMDA neurotoxicity. Tranylcypromine (10 μg/g) causes an approximate and significant doubling of labeled cells in the combined brain regions examined, as detected by BrdU immunohistochemistry. Tranylcypromine causes the greatest increase in cell proliferation in the cerebellum.
相关产品:Covalent Screening Library Plus | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Epigenetics Compound Library | Neuronal Signaling Compound Library | FDA-Approved Drug Library | Histone Modification Research Compound Library | CNS-Penetrant Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Covalent Screening Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Anti-COVID-19 Compound Library | FDA Approved & Pharmacopeial Drug Library | Neuroprotective Compound Library | Drug-Induced Liver Injury (DILI) Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Mitochondria-Targeted Compound Library | Antidepressant Compound Library | Human Metabolite Library | Off-patent Drug Library | Highly Selective Inhibitors Library | GSK2879552 dihydrochloride | KDM2B-IN-3 | KDM4-IN-2 | Moclobemide N-Oxide | LSD1/ER-IN-1 | MAO-B-IN-9 | GSK-J4 hydrochloride | Hypericin | Lenumlostat | Homopterocarpin | Bomedemstat hydrochloride | MAO-B-IN-13 | LSD1-IN-18 | KDM4-IN-4 | (1S,2R)-Tranylcypromine hydrochloride | Pulrodemstat benzenesulfonate | PXS-4681A | Safinamide mesylate | GSK-J1 lithium salt | Phenelzine sulfate | Amitraz | CPI-4203 | Contezolid acefosamil sodium | hMAO-B-IN-2 | 1,4-Naphthoquinone-d6 | Pivalylbenzhydrazine | Monoamine oxidase | MAO-A/B-IN-2 | MAO A/HDAC-IN-1 | JQKD82
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。