MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 117570-53-3
MCE 国际站:Vadimezan
产品活性:Vadimezan (DMXAA; ASA-404) 是血管破坏剂,是鼠干扰素基因 (STING) 刺激物,也是 I 型 IFN 和其他细胞因子的强效诱导剂。Vadimezan 具有抗流感病毒 H1N1-PR8 的活性。
研究领域:Immunology/Inflammation | Anti-infection
作用靶点:STING | IFNAR | Influenza Virus
In Vitro: Vadimezan (DMXAA), the vascular disrupting agent, is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan (DMXAA) has no detrimental effect on 344SQ-ELuc cell viability. It is found that Vadimezan-mediated up regulation of the NF-κB pathway as shown by increased p65 phosphorylation in M2 macrophages. Results demonstrate that Vadimezan (DMXAA)-treated cells are protected from VSV-induced cytotoxicity at all MOIs in contrast to medium-pretreated macrophages. Vadimezan (DMXAA) effectively inhibits growth of both strains of influenza, demonstrating the potential of Vadimezan for treatment of drug-resistant strains of human influenza.
In Vivo: 344SQ-ELuc NSCLC subcutaneous tumors respond dramatically to Vadimezan (DMXAA), with a marked decrease in bioluminescence (BLI) signals post-drug injection. Vadimezan (DMXAA) treatment of 344SQ-ELuc metastases yields no decrease in photon emission rates, with the tumors remaining histologically similar to controls after this treatment. As with the large subcutaneous tumors, Vadimezan (DMXAA) administration to mice with small subcutaneous tumors still leads to ~2-log decreases in photon emission at both 6 and 24 hours. In vivo, Vadimezan (DMXAA) is a more potent inducer of IFN-β mRNA and a relatively poor inducer of TNF-α mRNA. Vadimezan (DMXAA) administration leads to significantly less weight loss in influenza-infected mice.
相关产品:Natural Product-like Compound Library | Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | Anti-Cancer Compound Library | Clinical Compound Library | Antiviral Compound Library | Small Molecule Immuno-Oncology Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | Pyroptosis Compound Library | Anti-Lung Cancer Compound Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Ganoderic acid TR | Emapalumab | Curcumin | Lactimidomycin | Cap-dependent endonuclease-IN-23 | Cyclic-di-GMP disodium | Ermanin | Hypericin | Dazostinag disodium | Antiviral agent 20 | Trifluoperazine dihydrochloride | 1-Deoxymannojirimycin hydrochloride | STING-IN-2 | Rimantadine-d4 hydrochloride | CL845-PAB-Ala-Val-C5-MC | FR198248 | Amantadine-d6 | CEF1, Influenza Matrix Protein M1 (58-66) | Drechslerine A | Ginsenoside F3 | SP187 | Ketotifen fumarate | Herquline A | Coptisine chloride | Ginsenoside Rb2 | STING agonist-13 | RO8191 | Sophocarpine monohydrate | Amantadine
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。