MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

CCT251545

CAS No. : 1661839-45-7

MCE 国际站：CCT251545

产品活性：CCT251545 是一种口服生物有效的 WNT 抑制剂, 在 7dF3 细胞中对 WNT 抑制作用的 IC₅₀ 值为 5 nM。CCT251545 是一种选择性化学探针，用于探索 CDK8 和 CDK19 在人类疾病中的作用。

研究领域：Stem Cell/Wnt

作用靶点：Wnt

In Vitro: CCT251545 potently inhibits WNT pathway activity in COLO205-F1756 clone 4 (an APC -mutant human colorectal cancer cell line engineered to express a modified luciferase-based WNT reporter construct) with an IC₅₀ of 0.035 μM.
CCT251545 has weak inhibition of tankyrase enzymes (TNKS1 IC₅₀ > 10 μM, TNKS2 IC₅₀ = 15.0).
CCT251545 is a potent and selective chemical probe for the human mediator complex-associated protein kinases CDK8 and CDK19 with >100-fold selectivity over 291 other kinases.
CCT251545 alters WNT pathway-regulated gene expression and other on-target effects of modulating CDK8 and CDK19, including expression of genes regulated by STAT1.
CCT251545 also reduces phospho-STAT1^SER727 levels in SW620 cells with an IC₅₀ of 9 nM.
CCT251545 displays potent cell-based activity.

In Vivo: CCT251545 (70mg/kg; p.o.; twice daily) causes an inhibition of tumor growth in NCr athymic mice bearing established SW620 human colorectal cancer xenografts.

相关产品：Bioactive Compound Library Plus  |  Stem Cell Signaling Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Differentiation Inducing Compound Library  |  Cytoskeleton Compound Library  |  Orally Active Compound Library  |  Chemical Probe Library  |  Neuroprotective Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Liver Cancer Compound Library   |  Anti-Colorectal Cancer Compound Library   |  Anti-Prostate Cancer Compound Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Cancer Stem Cells Compound Library  |  Heterocyclic Compound Library  |  Antihypertensive Compound Library  |  Highly Selective Inhibitors Library  |  FzM1  |  Pamidronic acid  |  Fz7-21  |  NSC668036  |  JW67  |  Ipafricept  |  Ipivivint  |  WIC1  |  JW74  |  IQ 1  |  Heparan Sulfate  |  L-Quebrachitol  |  ETC-159  |  HLY78  |  Cardiogenol C hydrochloride  |  Laduviglusib (GMP)  |  FzM1.8  |  OM-153  |  NLS-StAx-h TFA  |  UU-T02  |  Wnt/β-catenin agonist 4  |  Wnt-C59  |  Wogonin  |  BML-284 hydrochloride  |  ABC99  |  NCB-0846  |  Echinacoside  |  Neurodazine  |  Dinactin  |  Triptonide

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。