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CAS No. : 163769-88-8
MCE 国际站:YM-90709
产品活性:YM-90709 是一种常规的 IL-5 阻断剂,选择性的抑制 IL-5 与 IL-5 受体结合。YM-90709 能有效抑制 [125I]-IL-5 与 IL-5R 在人外周嗜酸性粒细胞和嗜酸性 HL-60 克隆 15 细胞上的结合,IC50 值分别为 1.0 和 0.57 μM。
研究领域:Immunology/Inflammation
作用靶点:Interleukin Related
In Vitro: YM-90709 (0-100 μM;1 hour) inhibits the binding of [125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells.
YM-90709 (0-100 μM; 96 hour; Eosinophilic HL-60 clone 15 cells) affects IL-5 and GM-CSF and prolonged the survival time of eosinophils.
YM-90709 (0-100 μM; 5 min; Eosinophilic HL-60 clone 15 cells) inhibits IL-5-induced, but not GM-CSF-induced, eosinophil survival as well as the tyrosine phosphorylation of Janus kinase 2.
In Vivo: YM-90709 (0.01-10 mg/kg; intravenous injection, 72 hours, Inbred female Brown-Norway (BN) rats) results in the inhibition of antigen-induced infiltration of eosinophils and lymphocytes, but not neutrophils or monocytes, into the bronchoalveolar lavage fluid (BALF) of Brown-Norway (BN) rats.
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