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CAS No. : 312756-74-4
MCE 国际站:RS-1
产品活性:RS-1 是一种 RAD51 的激活剂,同时可增强 CRISPR/Cas9 的活性。
研究领域:Cell Cycle/DNA Damage
作用靶点:RAD51 | CRISPR/Cas9
In Vitro: RS-1 is a RAD51 activator, stimulating binding of hRAD51 to DNA with Kd ranging from 48 nM to 107 nM in the presence of ATP or ADP and in the absence of a nucleotide cofactor, and such an effect is not via inhibiting its ATPase activity. RS-1 (20 μM) affects the length and helical pitch of hRAD51 protein-DNA complexes. RS-1 (0, 1, 5, 10, 15, 20, and 25 μM) stimulates strand assimilation activity of hRAD51. RS-1 (7.5 μM) promotes resistance of human cells to cross-linking chemotherapy. RS-1 (0, 7.5, 15 μM) increases Cas9-mediated knock-in efficiencies in rabbit embryos.
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