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CAS No. : 80734-02-7
MCE 国际站:Lenampicillin hydrochloride
产品活性:Lenampicillin hydrochloride (KBT 1585 hydrochloride) 是氨苄西林的口服前体,是一种有效的-内酰胺类抗菌(beta-lactam antibacterial) 剂,可抑制细菌的青霉素结合蛋白(转肽酶)。与氨苄西林相比,Lenampicillin 有改善吸收、减少副作用的作用,并应用于化脓性皮肤软组织感染的研究。
研究领域:Anti-infection
作用靶点:Bacterial
In Vivo: Lenampicillin hydrochloride (KBT-1585) (oral adminstration; 0-1000 mg/kg) does not lead to death in dogs, and maximum dose of in this acute toxicity study is recorded because of causing emesis.Lenampicillin hydrochloride (LAPC) are identified for it main metabolites in rat and dogs. The main metabolite in peripheral plasma is 2,3-butanediol in rats and dog, On the other hand, high levels of acetoin is found in portal plasma for early period after dosing of LAPC. These results shows that the biotransformation of promoiety in LAPC to acetoin carried out mainly in intestinal tissues, but acetoin is converted to 2,3-butanediol in liver.
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