MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Crenigacestat

CAS No. : 1421438-81-4

MCE 国际站：Crenigacestat

产品活性：Crenigacestat (LY3039478) 是具有口服活性的 Notch 和 γ-secretase 的抑制剂，其在多种肿瘤细胞中的 IC₅₀ 为 ∼1nM。

研究领域：Neuronal Signaling  |  Stem Cell/Wnt

作用靶点：Notch  |  γ-secretase

In Vitro: Crenigacestat (100 nM) exhibits anti-cancer activity in K07074 cells (a primary mouse liver tumor cell line).
Crenigacestat (LY3039478) decreases expression of Myc and cyclin A1 (part of the NOTCH-driven proliferative signature) in murine and human model systems. Crenigacestat (LY3039478) treatment also leads to G0/G1 cell cycle arrest in CCRCC cells.

In Vivo: Crenigacestat (8 mg/kg, oral gavage three times a week) resulted in significantly increases survival and delayed tumor growth in independent cohorts of mice demonstrating in vivo efficacy in CCRCC.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Neuronal Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Wnt/Hedgehog/Notch Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Differentiation Inducing Compound Library  |  Reprogramming Compound Library  |  Anti-COVID-19 Compound Library  |  Orally Active Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Angiogenesis-Related Compound Library  |  Transcription Factor-Targeted Library  |  Anti-Liver Cancer Compound Library   |  Anti-Colorectal Cancer Compound Library   |  Cancer Stem Cells Compound Library  |  Heterocyclic Compound Library  |  Membrane Protein-targeted Compound Library  |  Tarlatamab  |  FLI-06  |  gamma-secretase modulator 3  |  RO7185876  |  FRM-024  |  3,5-Bis(4-nitrophenoxy)benzoic acid  |  Valproic acid-d₆  |  PF-06648671  |  Valproic acid-d₄-1  |  DAPT (GMP)  |  ELN318463 racemate  |  Nirogacestat dihydrobromide  |  LY-411575 (isomer 3)  |  (Rac)-BIIB042  |  Jagged-1 (188-204) (TFA)  |  Psoralidin  |  BMS 433796  |  Aβ42-IN-1  |  Carvacrol  |  Valproic acid-d₁₅  |  Valproic acid (sodium)(2:1)  |  LY900009  |  ZLDI-8  |  Brontictuzumab  |  Rovalpituzumab  |  Valproic acid-d₇ sodium  |  (E/Z)-Sulindac sulfide  |  RA-V

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。