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CAS No. : 2641079-92-5
MCE 国际站:CK2 inhibitor 2
产品活性:CK2 inhibitor 2 是一种有效的,选择性和具有口服活性的 CK2 抑制剂,IC50 值为 0.66 nM。CK2 inhibitor 2 对 Clk2 (IC50=32.69 nM)/CK2 显示出高选择性。 CK2 inhibitor 2 具有良好的抗增殖和抗肿瘤活性。
研究领域:Cell Cycle/DNA Damage | Stem Cell/Wnt
作用靶点:Casein Kinase
In Vitro: CK2 inhibitor 2 (compound 1c) exhibits potent antiproliferative activities against PC-3, HCT-116, MCF-7, HT-29, T24 and LO2 cells, with IC50s of 4.53 μM, 3.07 μM, 7.50 μM, 5.18 μM, 6.10 μM, and 96.68 μM, respectively.
CK2 inhibitor 2 (5-20 μM; 24 h) induces apoptosis of HCT-116 cells in a dose-dependent manner. CK2 inhibitor 2 dose-dependently suppresses the expression of p-Akt1S129 and p-Cdc37S13 in HCT-116 cells.
CK2 inhibitor 2 (1-500 nM) dose-dependently inhibits exogenous ALDH1A1 enzyme activity, with an IC50 of 0.10 μM.
CK2 inhibitor 2 (5-20 μM; 24 h) inhibits the transcription and protein expression of ALDH1A1 in HCT-116 cells.
In Vivo: CK2 inhibitor 2 (60-90 mg/kg; p.o. twice a day for 4 weeks) obviously inhibits the tumor growth dose-dependently with a maximum inhibitory rate of 69% at a dose of 90 mg/kg.
CK2 inhibitor 2 (25 mg/kg; a single p.o.) exhibits Cmax (7017.8 ng/mL), elimination half-life (t1/2=6.67 h), and CL (0.60 L/h/kg) in SD rats.
相关产品:Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Kinase Inhibitor Library | Stem Cell Signaling Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Orally Active Compound Library | Targeted Diversity Library | Cancer Stem Cells Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | CK2-IN-4 | Umbralisib hydrochloride | 4,5,6,7-Tetrabromo-1H-benzimidazole | JNJ-6204 | CK2-IN-1 | PF-5006739 | TA-01 | Ellagic acid | EGFR-IN-57 | AMG-548 hydrochloride | CKI-7 free base | SR-1277 | CK2α-IN-1 | NCC007 | Emodin-d4 | Casein Kinase II Inhibitor IV | TMX-4113 | BTX161 | D4476 | Casein Kinase II Receptor Peptide | PI-828 | TBCA | TTP 22 | Longdaysin | CK2/ERK8-IN-1 | TMCB | Silmitasertib sodium salt
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