MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

WSB1 Degrader 1

CAS No. : 2306039-66-5

MCE 国际站：WSB1 Degrader 1

产品活性：WSB1 Degrader 1 是一种有效的具有口服活性的 WSB1 (WD repeat and SOCS box-containing 1) 降解剂。WSB1 Degrader 1 具有抗癌转移作用。

研究领域：Metabolic Enzyme/Protease

作用靶点：E1/E2/E3 Enzyme

In Vitro: WSB1 Degrader 1 (compound 4; 0.25-2500 nM; 2-24 hours; H1299-WSB1 cells) treatment indues WSB1 degradation in time-dependent and dose-dependent manners.
WSB1 Degrader 1 (compound 4) exhibits potent antimigration efficacy in both KHOS and H460 cell lines with IC₅₀ values of 39.1 μM and 24.47 μM, respectively.
WSB1 Degrader 1 (compound 4) significantly inhibits cancer cell migration under normoxia and hypoxia in KHOS cells. WSB1 Degrader 1 (5 μM) treatment elevates the levels of the RhoGDI2 protein in KHOS cells under hypoxia.
The wound-healing of H1299-WSB1 cells is significantly inhibited by treating with WSB1 Degrader 1. WSB1 Degrader 1 can only block the wound-healing capability of wild-type A2780 (A2780-WT) cells but not the A2780-WSB1/KO cells.

In Vivo: WSB1 Degrader 1 (compound 4; 100 mg/kg; p.o.; daily; for 28 days) treatment can effectively inhibit the pulmonary metastasis of cancer cells.
In rats, after 100 mg/kg oral dosing or 160 mg/kg intraperitoneal dosing of WSB1 Degrader 1 (compound 4), the two ways of administration are observed with quick absorption (Tmax), but the former dosing displayed a fast clearance (T_1/2). Moreover, C_max and AUC_0-t values of WSB1 Degrader 1 in oral or intraperitoneal dosing groups showed acceptable blood exposure.

相关产品：Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  Anti-Cancer Compound Library  |  Oxygen Sensing Compound Library  |  Ubiquitination Compound Library  |  Orally Active Compound Library  |  Anti-Liver Cancer Compound Library   |  Heterocyclic Compound Library  |  GS143  |  p53 and MDM2 proteins-interaction-inhibitor (racemic)  |  Navtemadlin  |  MX69  |  RG7112  |  MD-224  |  WS-383 free base  |  Ubiquitination-IN-1  |  UbcH5c-IN-1  |  p53-MDM2-IN-1  |  PROTAC MDM2 Degrader-1  |  Skp2 inhibitor 1  |  BC1618  |  C25-140  |  Avadomide  |  RO-5963  |  DCN1-UBC12-IN-2  |  Hinokiflavone  |  SENP1-IN-2  |  Nutlin-3  |  SENP1-IN-1  |  PYR-41  |  SZL P1-41  |  TAK-243  |  NSC624206  |  Cbl-b-IN-1  |  Milademetan  |  Rugonersen

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。