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CAS No. : 427-51-0
MCE 国际站:Cyproterone acetate
产品活性:Cyproterone acetate 是一种抗雄激素 (IC50=7.1 nM) 和孕激素合成的类固醇。Cyproterone acetate 与 progesteron 和糖皮质激素受体有亲和力。
研究领域:Vitamin D Related/Nuclear Receptor
作用靶点:Androgen Receptor
In Vitro: Cyproterone acetate is a partial agonist, showing agonism for the AR, with EC50 of 4.0 μM, at relatively high concentrations.
Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5.
Cyproterone acetate pretreatment (0,1,10, or 50 μM; 24 hours; subsequently exposed to cadmium for an additional 24 hours) resulted in a clear decrease in the sensitivity to cadmium in rat liver epithelial cell line.
In Vivo: Adult male C57 BL/6J mice injected with 0.08 mg/g of cyproterone acetate showed an increase in cellular lipid content in the zona fasciculata and zona retjculans of the adrenal cortex.
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