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CAS No. : 154-93-8
MCE 国际站:Carmustine
产品活性:Carmustine 是一种抗肿瘤化疗剂,为 DNA 和 RNA 的烷化剂 (alkylator)。
研究领域:Cell Cycle/DNA Damage
作用靶点:DNA Alkylator/Crosslinker
In Vitro: Carmustine is an antitumor chemotherapeutic agent. Carmustine (8, 80, and 800 μM) decreases N-acetyltransferase (NAT) activities for 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) in rat glial tumor cytosol and intact cells. In rat glial tumor cells, the DNA-AF adduct increases, and carmustine decreases the formation of DNA-AF adduct.
In Vivo: Carmustine (BCNU; 25 mg/kg, i.p.) causes higher levels of the rhe ratio of liver weight to body weight and plasma conjugated bilirubin, and lower biliary flow, oxidised glutation levels (GSSG) and reduced glutation (GSH)/GSSG values compared with control rats.
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