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Eflornithine

CAS No. : 70052-12-9

MCE 国际站：Eflornithine

产品活性：Eflornithine (DFMO) 是酶鸟氨酸脱羧酶的特异性不可逆抑制剂。Eflornithine 可用于研究非洲锥虫病和女性面部毛发过度生长。

研究领域：Anti-infection

作用靶点：Parasite

In Vivo: Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension.

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