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CAS No. : 61-73-4
MCE 国际站:Methylene Blue
产品活性:Methylene blue (Basic Blue 9) 是一种鸟苷酸环化酶 (sGC),单胺氧化酶 A (MAO-A) 和 NO 合酶 (NOS) 抑制剂。Methylene blue 是一种血管加压剂,在医疗中通常用作染料。Methylene blue 通过一氧化氮合成酶/鸟苷酸环化酶信号通路降低脉冲前抑制。Methylene blue 是一种氧化还原循环化合物,能够穿过血脑屏障。Methylene blue 是 Tau 聚集抑制剂。亚甲蓝可减轻脑水肿,减弱小胶质细胞活化,减少神经炎症。
研究领域:GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation | Cytoskeleton | Cell Cycle/DNA Damage
作用靶点:Guanylate Cyclase | Monoamine Oxidase | NO Synthase | Microtubule/Tubulin
In Vitro: Methylene blue (Basic Blue 9) (4.5 μM; BV2 microglia) alters the immune profile of LPS-activated BV2 microglia and decreases the level of CD14, IL-1β, TNF-α, and CCL2 mRNA.
In Vivo: Methylene blue (Basic Blue 9) (50 and 100 mg/kg; i.p.; once, for 25 min; male NMRI mice) reduces absent prepulse inhibition.
Methylene blue (Basic Blue 9) (20 and 40 mg/kg; p.o.; daily, for 6 months; CaMKIIα-tTA transactivator mice) preserves cognition in mice expressing full-length pro-aggregant human Tau.
Methylene blue (Basic Blue 9) (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces TBI-induced edema and neuroinflammation and reduces acute depression-like behavior.
Methylene blue (Basic Blue 9) (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces the percentage of inflammatory factor.
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