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CAS No. : 99592-39-9
MCE 国际站:Sertaconazole nitrate
产品活性:Sertaconazole nitrate (FI7056) 是一种局部广谱的抗真菌剂,可通过激活 p38-COX-2-PGE 2 通路来发挥抗炎活性。Sertaconazole nitrate 也是一种微管蛋白抑制剂,具有抗癌细胞增殖活性,诱导细胞的凋亡和自噬,还能抑制细胞的迁移,具有较好的抗癌活性。
研究领域:Anti-infection | Autophagy | Apoptosis | MAPK/ERK Pathway | Cytoskeleton | Cell Cycle/DNA Damage
作用靶点:Fungal | Autophagy | Apoptosis | p38 MAPK | Microtubule/Tubulin
In Vitro: Sertaconazole nitrate (0.03-40 µg/mL; 24 h) inhibits 150 strains of yeasts which includes six Candida species with arithmetic mean MIC of 0.77 µg/mL.
Sertaconazole nitrate (1 µg/mL; 5, 10, 30, 60 min) activates p38 MAP kinase in a time-dependent manner.
Sertaconazole nitrate (1, 2 µg/mL; 6, 8, or 24 h) increases a twofold release of PGE2 via COX-2 in keratinocytes, which is dependent on p38 activation.
Sertaconazole nitrate (10, 20, 30, 40 µM; 24 h) induces strong mitotic arrest by depolymerizing interphase and spindle microtubules, thereby inducing chromosome aggregation defects and causing anti-proliferation effect.
Sertaconazole nitrate (20, 40 µM; 24 h) induces apoptosis through p53 pathway in HeLa cells.
Sertaconazole nitrate (20, 30 µM; 24, 48, and 72 h) inhibits the migration of HeLa cells in a concentration-dependent manner.
Sertaconazole nitrate (15, 30 µM; 24 h) induces autophagy in A549, H460 cells.
In Vivo: Sertaconazole nitrate (1% (w/v); apply to the left ear, once) suppresses of TPA-induced ear edema CD-1 mice.
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