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AK-7

CAS No. : 420831-40-9

MCE 国际站：AK-7

产品活性：AK-7 是一种可透过细胞及血脑屏障的 SIRT2 抑制剂，IC₅₀ 值为 15.5 μM。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶点：Sirtuin

In Vitro: AK-7 (10 μM) reduces cholesterol levels in naive N2a neuroblastoma cells and hippocampal slice cultures from wild-type mice. AK-7 (1 μM) shows neuroprotective effect of AK-7 in striatal Huntington’s disease (HD) neurons. AK-7 (12.5 μM) decreases ratio of DA neurons in primary midbrain cultures.

In Vivo: AK-7 (15 mg/kg/dose, i.p.) is brain-permeable in wild-type and HD mice. AK-7 (10, 20 mg/kg, i.p.) improves the behavior and neuropathological phenotype and extends survival of R6/2 HD mice. AK-7 (20 mg/kg) ameliorates HD neuropathology in R6/2 mice. AK-7 also reduces the polyglutamine aggregation in R6/2 brain. In addition, AK-7 treated 140CAG mice show motor performance changes that parallel untreated wild-type mice, with the 20 mg/kg dose being most effective and significantly different from untreated 140CAG mice.

相关产品：Bioactive Compound Library Plus  |  Cell Cycle/DNA Damage Compound Library  |  Epigenetics Compound Library  |  Histone Modification Research Compound Library  |  CNS-Penetrant Compound Library  |  Anti-Aging Compound Library  |  Antioxidant Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Glutamine Metabolism Compound Library  |  Neuroprotective Compound Library  |  Highly Selective Inhibitors Library  |  E1231  |  Cambinol  |  PROTAC Sirt2 Degrader-1  |  Resveratrol  |  SRT 1720 Hydrochloride  |  SIRT-IN-3  |  SRT 2104  |  Tenovin-6  |  Ganoderic acid D  |  Decapeptide-12  |  SIRT2-IN-11  |  AK-1  |  UBCS039  |  SIRT1-IN-2  |  CypD-IN-4  |  SIRT-IN-1  |  SIRT5 inhibitor 2  |  Sirt2-IN-1  |  SIRT1-IN-1  |  SRTCX1002  |  Nicotinamide riboside tartrate  |  Inauhzin  |  Nicotinamide-¹⁵N,¹³C₃  |  SRTCX1003  |  SIRT5 inhibitor 3  |  Sirtuin modulator 4  |  YK-3-237  |  SIRT5 inhibitor 4  |  SRT 1460  |  AC-93253

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