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CAS No. : 1047953-91-2
MCE 国际站:MALT1 inhibitor MI-2
产品活性:MALT1 inhibitor MI-2 是一种 MALT1 抑制剂 (IC50=5.84 μM),MALT1 inhibitor MI-2 直接与 MALT1 结合,不可逆地抑制蛋白酶功能,并伴有 NF-κB 报告子活性抑制、c-REL 核定位抑制和 NF-κB 靶基因下调。MALT1 inhibitor MI-2 对动物无毒。
研究领域:Metabolic Enzyme/Protease | NF-κB
作用靶点:MALT1
In Vitro: MALT1 inhibitor MI-2 (1-1000 nM; 48 hours) selectively suppresses MALT1-dependent DLBCL cell lines, and the GI50 in HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells is 0.2, 0.5, 0.4, and 0.4 µM, respectively.
MALT1 inhibitor MI-2 (62-1000 nM; 24 hours) causes a dose-dependent decrease in MALT1-mediated cleavage.
In Vivo: MALT1 inhibitor MI-2 (25 mg/kg; i.p.; daily for 14 days) profoundly suppresses the growth of both the TMD8 and HBL-1 ABC-DLBCL xenografts.
相关产品:Covalent Screening Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Targeted Diversity Library | Cysteine Targeted Covalent Library | MALT1-IN-3 | MLT-943 | MLT-231 | Mepazine hydrochloride | MALT1-IN-5 | MALT1-IN-6 | MALT1-IN-7 | MLT-747 | RGT-068A | MLT-748 | MALT1-IN-9 | NVS-MALT1 | (R)-MLT-985 | Z-VRPR-FMK TFA | Val-Arg-Pro-DL-Arg-Fluoromethylketone | MALT1-IN-8 | MALT1-IN-11 | Safimaltib
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