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Losmapimod

CAS No. : 585543-15-3

MCE 国际站：Losmapimod

产品活性：Losmapimod (GSK-AHAB) 是一种有效的，具有口服活性的选择性 p38 MAPK 抑制剂，抑制 p38α 和 p38β 的 pK_i 值分别为 8.1 和 7.6。

研究领域：MAPK/ERK Pathway  |  Autophagy

作用靶点：p38 MAPK  |  Autophagy

In Vivo: In the spontaneously hypertensive stroke-prone rat (SHR-SP), chronic treatment with GSK-AHAB significantly and dose-dependently improves survival, endothelial-dependent and -independent vascular relaxation, and indices of renal function, and it attenuates dyslipidemia, hypertension, cardiac remodeling, plasma renin activity (PRA), aldosterone, and interleukin-1β (IL-1β).

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