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Tofogliflozin (hydrate)

CAS No. : 1201913-82-7

MCE 国际站：Tofogliflozin (hydrate)

产品活性：Tofogliflozin hydrate (CSG-452 hydrate) 是一种有效的，高度特异性的和选择性的 SGLT2 抑制剂，其 IC₅₀ 值为 2.9 nM，对人、大鼠和小鼠 SGLT2 的 K_i 值分别为 2.9 nM，14.9 nM 和 6.4 nM。Tofogliflozin hydrate 部分抑制肾小管细胞中高葡萄糖诱导的 ROS 生成。

研究领域：Membrane Transporter/Ion Channel  |  Metabolic Enzyme/Protease  |  Immunology/Inflammation  |  NF-κB

作用靶点：SGLT  |  Reactive Oxygen Species

In Vitro: Tofofloxacin (3-30 nM; 24 hours; tubular epithelial cells) treatment inhibits the oxidative stress generation and monocyte chemoattractant protein-1 (MCP-1) gene expression in tubular cells induced by high glucose.
Tofofloxacin (3-30 nM; 8 days; tubular epithelial cells) treatment inhibits the apoptotic cell death induced by high glucose.

In Vivo: Tofogliflozin (0.1-10 mg/kg; oral administration; once daily; for 4 weeks; db/db mice) treatment improves hyperglycemia and thereby ameliorated glucose intolerance of the obese diabetic mice.

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