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Mebendazole

CAS No. : 31431-39-7

MCE 国际站：Mebendazole

产品活性：甲苯达唑是一种高效、广谱的抗线虫药。甲苯达唑对多形性乳腺母细胞瘤 (GBM) 也有抑制作用，抑制 Hedgehog 通路和微管蛋白 (tubulin) 聚合。甲苯达唑具有口服活性，可透过血脑屏障。

研究领域：Anti-infection  |  Apoptosis  |  Cell Cycle/DNA Damage  |  Cytoskeleton

作用靶点：Parasite  |  Apoptosis  |  Microtubule/Tubulin

In Vitro: Mebendazole (1 nM-0.1 mM; 72 h) shows inhibition of GL261 mouse glioma cells with IC₅₀ value of 0.24 μM.
Mebendazole (0.1 μM and 1 μM; 24 h) disrupts microtubule polymerization and microtubule structure in 060919 glioblastoma multiforme (GBM) cells.
Mebendazole (10 nM-10 μM; 48 h) inhibits Hh signaling and reduces the expression of downstream Hh pathway effectors, by decreasing Gli1 transcript and protein expression in tumor tissues. Mebendazole inhibits Gli1 expression with an IC₅₀ value of 516 nM.
Mebendazole (10 nM-10 μM; 48 h) prevents the formation of the primary cilium, and decreases the proliferation and survival of human medulloblastoma cells with constitutive Hh activation.
A combination of mebendazole and Vismodegib (HY-10440) achieved additive inhibition of canonical Hh signaling.
Mebendazole has effectively treated CNS echinococcosis in numerous clinical settings before, indicating significant CNS penetration property.

In Vivo: Mebendazole (50 mg/kg; p.o.; once daily for first 20 d and 5 d per week with 2 d off; 45 d) inhibits intracranial tumor growth in the syngeneic GL261 mouse model and 060919 human glioblastoma multiforme (GBM) xenograft mouse model.

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