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CAS No. : 52205-73-9
MCE 国际站:Estramustine phosphate sodium
产品活性:Estramustine phosphate sodium,一种雌二醇类似物,是一种具有口服活性的抗微管化疗剂。Estramustine phosphate sodium 通过与微管相关蛋白 (MAP) 和/或微管蛋白结合而使微管解聚。Estramustine phosphate sodium 可干扰有丝分裂,引发细胞死亡,以及诱导细胞凋亡 (apoptosis),可用于前列腺癌等癌症相关的研究。
研究领域:Cell Cycle/DNA Damage | Cytoskeleton | Apoptosis
作用靶点:Microtubule/Tubulin | Apoptosis
In Vitro: Estramustine phosphate sodium (1 µg/ mL, 48 h) suppresses PC3 cell growth.Estramustine phosphate sodium (2 µg/mL, 48 h) elevates phosphatidylserine eversion amount on PC3 cells and induces PC3 cell apoptosis through reducing miR-31.Estramustine phosphate sodium (0-40 µM, 24-72 h) inhibits cell proliferation and tubulin cytoskeleton in RAW 264.7 cells.Estramustine phosphate sodium (10 µM, 24 h) inhibits TGF-β-induced RAW 264.7 cell migration, as well as TGF-β-induced uPA production by inhibiting Smad3 activation.
In Vivo: Estramustine phosphate sodium (Intraperitoneal injection, 4 or 12 mg/kg, a daily dose for 2 weeks) inhibits PAC120 tumor growth 53% by day 35.
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