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CAS No. : 256498-66-5
MCE 国际站:BAY 41-8543
产品活性:BAY 41-8543 是口服有效的,不依赖一氧化氮 (NO) 的可溶性鸟苷酸环化酶 (sGC) 的刺激物。BAY 41-8543 在大鼠的肺和全身血管床中具有血管舒张活性。BAY 41-8543 具有抗血小板作用,并有用于心血管疾病研究的潜力。
研究领域:GPCR/G Protein
作用靶点:Guanylate Cyclase
In Vivo: BAY 41-8543 (10-100 μg/kg; IV) produces small decreases in pulmonary arterial pressure, larger dose-dependent decreases in systemic arterial pressure, and increases in cardiac output.
BAY 41-8543 (0.003, 0.01, 0.03, 0.1, and 0.3 mg/kg; iv) produces a dose-dependent and long-lasting decrease in blood pressure in anaesthetized rats. The blood pressure lowering effect of BAY 41-8543 lasts longer than the observation period of 30 min. BAY 41-8543 (0.1, 0.3 and 1.0 mg kg; oral) has maximal blood pressure lowering effects. The blood pressure lowering effects of the highest doses of BAY41-8543 lasts longer than the observation period of 120 min.
BAY 41-8543 (3 mg/kg; p.o.; twice daily; for 5 weeks) completely prevents the development of the increase in systolic blood pressure in 18-week-old renin transgenic rats (TGR(mRen2)27) on L-NAME treatment. BAY 41-8543 dramatically increases survival.
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