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Simotinib

CAS No. : 944258-89-3

MCE 国际站：Simotinib

产品活性：Simotinib 是一种选择性、特异性、口服生物利用度高的 EGFR 酪氨酸激酶抑制剂，IC₅₀ 为 19.9 nM。抗肿瘤活性。

研究领域：JAK/STAT Signaling  |  Protein Tyrosine Kinase/RTK

作用靶点：EGFR

In Vitro: Simotinib inhibits in a dose-dependent manner EGFR and the growth of human A431 tumor cells with high expression of EGFR, with no significant activity on other investigated kinases.

In Vivo: Simotinib has been shown to exert its antitumor activity by inhibiting EGFR phosphorylation in nude xenograft model.

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