MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 751475-53-3
MCE 国际站:Atopaxar
产品活性:Atopaxar (E5555) 是一种高效、有口服活性活性的,选择性的,可逆的凝血酶受体蛋白酶激活受体-1 (PAR-1) 拮抗剂。Atopaxar 是一种抗血小板剂,能干扰血小板信号。Atopaxar 可用于动脉粥样硬化血栓性疾病的研究。
研究领域:GPCR/G Protein
作用靶点:Protease Activated Receptor (PAR)
In Vitro: Atopaxar (0.0001-10 μM; 1h) inhibits haTRAP (high-affinity thrombin receptor activating peptide) binding to PAR-1 on human platelet membranes in a concentration-dependent manner, with an IC50 of 0.019 μM.
Atopaxar inhibits human platelet aggregation induced by thrombin or TRAP in a concentration-dependent manner.
Atopaxar does not inhibit PRP (platelet-rich plasma) aggregation induced by ADP, U46619, collagen, and PAR-4ap, up to a concentration of 20 μM.
In Vivo: Atopaxar (30-100 mg/kg; p.o.) causes a dose-dependent prolongation of the time to occlusion of the femoral artery in photochemically-induced thrombosis (PIT) guinea pigs model.
Atopaxar does not prolong bleeding time in guinea pigs at the highest tested dosage of 1000 mg/kg.
相关产品:Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Anti-Cardiovascular Disease Compound Library | Orally Active Compound Library | Coagulation and Anti-coagulation Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Protease-Activated Receptor-3 (PAR-3) (1-6), human | I-191 | FSLLRY-NH2 TFA | VKGILS-NH2 | AC-55541 | FR-171113 | Protease-Activated Receptor-1 antagonist 3 | PAR-4 Agonist Peptide, amide TFA | Aeruginosin 98-B | AZ3451 | 2-Furoyl-LIGRLO-amide | AC-264613 | tcY-NH2 | ENMD-1068 hydrochloride | SLIGRL-NH2 | Protease-Activated Receptor-1, PAR-1 Agonist | CBK289001 | GB-110 hydrochloride | PAR-4 Agonist Peptide, amide | GB-88 | RWJ-56110 | Trypsin (MS grade) | AZ8838 | TRAP-6 | UDM-001651 | Parmodulin 2 | TFLLR-NH2 | Vorapaxar | SCH79797 dihydrochloride | TRAP-6-IN-1
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。