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CAS No. : 88349-90-0
MCE 国际站:A2793
产品活性:A2793 是有效的 TWIK 相关酸敏感 K+ 通道 1 (TASK-1)/TRESK 的抑制剂,其对 mTRESK 的 IC50 值为 6.8 μM。A2764 对 TRESK 选择性更好, 对 TREK-1 和 TALK-1 相对弱一些。
研究领域:Membrane Transporter/Ion Channel
作用靶点:Potassium Channel
In Vitro: A2793 (100 µM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5).
A2793 inhibits TASK-1 (100 µM, 53.4±13,5%, n=5), while A2764 is more selective for TRESK, it only moderately influencesTREK-1 and TALK-1.
A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1.
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