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CAS No. : 210584-54-6
MCE 国际站:Amustaline dihydrochloride
产品活性:Amustaline (S-303) dihydrochloride,一种靶向核酸的烷基化剂,是有效的病原体灭活剂,可用于含有红细胞的血液成分。Amustaline dihydrochloride 具有三个组成部分:吖啶固定物 (非共价靶向核酸的嵌入剂),效应子 (与亲核试剂反应的双烷基基团) 和连接子 (细的柔性碳链,其中含有不稳定的酯键,在中性 pH 下水解产生非反应性分解产物)。
研究领域:Anti-infection
作用靶点:HIV | Bacterial
In Vitro: S‐303 (200 μM; 20 h) and glutathione (GSH; 20 mM) inactivates high titres of Chikungunya virus (CHIKV) in red blood cells (RBCs).
S-303 (200 μM; 20 h) and GSH (2 mM) inactivates >6.5 logs of HIV, >5.7 logs of Bluetongue virus, >7.0 logs of Yersinia enterocolitica, 4.2 logs of Serratia marcescens, and 7.5 logs of Staphylococcus epidermidis in whole blood experiments.
S-303 (200 μM; 20 h) and GSH (20 mM) inactivates approximately 5 logs or greater of Y. enterocolitica, E. coli, S. marcescens, S. aureus, HIV, bovine viral diarrhoea virus, bluetongue virus and human adenovirus 5 in RBC.
S-303 (200 μM; 20 h) retains in vitro parameters of RBC function and physiology (including total ATP, extracellular potassium, hemolysis, glucose consumption, lactate production, and pH at 37 °C) compared to conventional RBC.
In Vivo: S‐303 RBCs (a single transfusion) is well tolerated in rats (50 μmol/kg) and dogs (70 μmol/kg).
S‐303 RBCs (repeated transfusions) is well tolerated in rats (10 μmol/kg) and dogs (10 μmol/kg) with no histopathologic evidence of organ toxicity.
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