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DC_AC50

CAS No. : 497061-48-0

MCE 国际站：DC_AC50

产品活性：DC_AC50 是 Atox1 和 CCS (铜伴侣蛋白) 的双抑制剂。抑制细胞内铜伴侣可作为减少/防止获得性化疗耐药的一种策略。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: DC_AC50 exhibits IC₅₀ values of 9.88 μM, 12.57 μM, 5.96 μM and 6.68 μM in Canine Abrams, Canine D1, human HOS and human MG63) cells, respectively.
?DC_AC50 (0-10 μM)-treated cells are significantly less mitotically active, as demonstrated by decreased expression of phospho-histone H3 and cell cycle analysis.
?DC_AC50 (10 μM) potentiates carboplatin-induced apoptosis in OSA cells and decreasesclonogenic survival.
?DC_AC50 induces cell cycle arrest at both the 3 and 10 μM doses and? DC_AC50 induces increase S phase cells dose-independently.
?DC_AC50 (3 μM) inhibits the migration and of canine and human OSA cells.
?DC_AC50 (2.5-10 μM) is highly efficient at inhibiting cancer cell proliferation (human lung cancer H1299 cells, leukaemia cancer K562 cells, breast cancer MDA-MB-231 cells and head and neck cancer 212LN cells) in a dose-dependent manner. DC_AC50 fails to exhibit any notable inhibition of the cell proliferation of human normal epithelial lung BEAS-2B cells or breast MCF-10A cells as control cells.

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