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hSMG-1 inhibitor 11e

CAS No. : 1402452-10-1

MCE 国际站：hSMG-1 inhibitor 11e

产品活性：hSMG-1 inhibitor 11e 是一种有效的选择性的 hSMG-1 激酶抑制剂，其 IC₅₀ 值 <0.05 nM。hSMG-1 inhibitor 11e 对 hSMG-1 的选择性比 mTOR (IC₅₀ 为 45 nM)，PI3Kα/γ (IC₅₀ 为 61 nM 和 92 nM) 和 CDK1/CDK2 (IC₅₀ 为 32 μM 和 7.1 μM) 高 900 倍。

研究领域：PI3K/Akt/mTOR  |  Cell Cycle/DNA Damage

作用靶点：mTOR  |  PI3K  |  CDK

In Vitro: hSMG-1 kinase plays a dual role in a highly conserved RNA surveillance pathway termed nonsense-mediated RNA decay (NMD) and in cellular genotoxic stress response. Since deregulation of cellular responses to stress contributes to tumor growth and resistance to chemotherapy, hSMG-1 is a potential target for cancer treatment.

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