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CAS No. : 182316-44-5
MCE 国际站:Cyclotriazadisulfonamide
产品活性:Cyclotriazadisulfonamide (CADA) 是一个特异性的 CD4 靶向的 HIV 进入抑制剂。Cyclotriazadisulfonamide (CADA) 以信号肽依赖的途径抑制 CD4 进入 内质网腔进行共翻译转位。Cyclotriazadisulfonamide 也是一种 Sec61 转位子抑制剂。
研究领域:Anti-infection
作用靶点:HIV
In Vitro: Cyclotriazadisulfonamide (CADA) significantly decreases the amount of cell surface CD4 -the main receptor for HIV -without altering the expression of any other cellular receptor examined so far.
Cyclotriazadisulfonamide (CADA) exhibits an EC50 of 0.4 μg/mL for CD4 in MO-DC cells. Treatment of MO-DC with 10 μg/mL of CADA results in 83% downregulation of cell surface CD4, an effect that is similar to that observed for CADA treatment of CD4+ T cells.
CADA prevents MT-4 cells from HIV-1 and SIV infection (EC50 are 0.7 and 1.2 g/ml, respectively).
Cyclotriazadisulfonamide is a Sec61 translocon inhibitor with a selective nature. A proteomics study on T-cells is performed and identified only five substrates (huCD4, SORT, CD137, DNAJC3, PTK7, ERLEC1) for Cyclotriazadisulfonamide, with IC50s of 0.2–2 µM.
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