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CAS No. : 58186-27-9
MCE 国际站:Idebenone
产品活性:Idebenone,一种线粒体保护剂,具有神经保护功效,可用于研究阿尔茨海默病、亨廷顿舞蹈病,可透过血脑屏障。Idebenone (氧化形式) 对星形胶质细胞匀浆中花生四烯酸的酶代谢具有抑制作用 (IC50=16.65 μM)。 Idebenone 是一种辅酶 Q10 类似物和抗氧化剂,在人多巴胺能神经母细胞瘤 SHSY-5Y 细胞中诱导细胞凋亡 (apoptotic)。
研究领域:Metabolic Enzyme/Protease | Apoptosis
作用靶点:Mitochondrial Metabolism | Apoptosis
In Vitro: Idebenone, a compound with protective efficacy against neurotoxicity both in in vitro and in in vivo models, exists in two different oxidative states: the ubiquinol-derivative (reduced idebenone) and the ubiquinone-derivative (oxidised idebenone).
Idebenone (oxidised form) preferentially inhibits cyclooxygenase vs. lipoxygenase metabolism (IC50 ratio lipoxygenase/cyclooxygenase: 3.22).
Idebenone (oxidised form) behaves similarly as indomethacin and piroxicam—two typical anti-inflammatory agents.
Idebenone (oxidised form) inhibits total arachidonic acid metabolism, cyclooxygenase metabolism, lipoxygenase metabolism, lipoxygenase/cyclooxygenase with IC50s of 16.65±3.48, 14.44±2.99, 46.51±7.20, and 3.22 μM.
Idebenone (1-10 μM; for 24-72 h) has no effect on the cell viability of SHSY-5Y cells.
Idebenone (25 μM or higher concentrations; for 24-72 h) shows significant reduction in cell viability of SHSY-5Y cells. Idebenone (30 μM) induces up-regulation of BAX expression and the caspase-3 activity.
In Vivo: Idebenone (oxidised form) is a compound with protective efficacy against cerebrovascular disorders in vivo, including cerebral ischemia and hypertension-induced vascular lesions.
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